Overview
Griseofulvin 125mg Tablets 100's contain griseofulvin, an oral antifungal medicine used to treat dermatophyte infections. Dermatophytes are fungi that affect keratin-containing tissues, including the skin, scalp, hair and nails. Treatment is generally considered when topical therapy is unsuitable or has not been effective, depending on the infection.
Mechanism of Action: How It Works
Griseofulvin interferes with fungal cell division by disrupting the formation of the structures fungi need to divide. It also accumulates in newly forming keratin, making new skin, hair and nails more resistant to invasion by susceptible fungi. As infected tissue grows out and is replaced by healthy tissue, the infection gradually clears. This is why treatment can take several weeks or longer.
Uses and Benefits
Griseofulvin may be prescribed for selected fungal infections, including:
Scalp ringworm (tinea capitis): a fungal infection of the scalp and hair.
Ringworm of the body (tinea corporis): circular or scaly fungal skin lesions.
Certain fungal infections of the feet or groin: where griseofulvin is considered appropriate.
Fungal nail infections: in selected cases, although treatment may be prolonged and other antifungals may be preferred.
Griseofulvin does not treat bacterial infections, viral infections or every type of fungal infection. The diagnosis should be confirmed by a healthcare professional.
Precautions and Warnings
Pregnancy: Griseofulvin is contraindicated during pregnancy. Anyone who is pregnant, may be pregnant or planning pregnancy should consult a healthcare professional before treatment.
Hormonal contraception: Griseofulvin can reduce the effectiveness of some hormonal contraceptives. Discuss additional or alternative contraception with your healthcare professional during treatment and for the recommended period afterwards.
Liver disease: Avoid use in severe liver disease; disclose any history of liver problems.
Lupus and porphyria: Griseofulvin is contraindicated in systemic lupus erythematosus and porphyria.
Sun sensitivity: The medicine may increase sensitivity to sunlight. Use protective clothing and sunscreen.
Drug interactions: Tell your healthcare professional about all medicines you take, particularly warfarin and hormonal contraceptives.
Alcohol: Avoid alcohol during treatment unless your prescriber confirms otherwise, as adverse reactions may occur.
Possible Side Effects
Possible side effects include:
Headache.
Nausea or stomach discomfort.
Vomiting or diarrhoea.
Dizziness or tiredness.
Increased sensitivity to sunlight.
Skin rash.
Seek medical advice promptly if you develop a severe rash, fever, mouth sores, yellowing of the skin or eyes, or other signs of a serious reaction.
